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HRA002966
   HRA002966.xlsx
Title:
A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR axis for the neurodevelopmental deficits of Williams Syndrome
Release date:
2024-09-02
Description:
Williams Syndrome (WS; OMIM#194050) is a rare disorder, which is caused by the microdeletion of one copy of 25-27 genes, and WS patients display diverse neuronal deficits. Although remarkable progress has been achieved, the mechanisms for these distinct deficits are still largely unknown. Here, we show that neural progenitor cells (NPCs) display abnormal proliferation and differentiation capabilities, synapse formation, and genes with altered expression that are related to neuronal development and neurogenesis in WS forebrain organoids by RNA seq.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA011621
Study type:
Disease Study
Disease name:
Williams-Beuren syndrome
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001720
DAC name:
Lilab
Contact person:
Li xuekun
Email:
xuekun_li@zju.edu.cn
Description:
The data is processed by DAC members
Individuals & samples
Files
Request Data
Submitter:   Li xuekun / xuekun_li@zju.edu.cn
Organization:   School of Medicine, Zhejiang University
Submission date:   2022-09-02
Requests:   2