Targeting oxidative protein folding reduces H2O2 and delays stem cell aging
Release date:
2022-09-06
Description:
Protein homeostasis is linked with aging and aging associated diseases. Oxidative protein folding occurs in the endoplasmic reticulum (ER) and produces H2O2 as a byproduct. The role of oxidative protein folding in human stem cells aging remains unknown. Here, we succeed to knockout protein disulfide isomerase (PDI), a key oxidoreductase for catalyzing oxidative protein folding, in human embryonic stem cells (hESCs) and human mesenchymal stem cells (hMSCs).
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Individuals & samples
Files
Submitter: Liu Guanghui / ghliu@ioz.ac.cn
Organization: Institute of Zoology, Chinese Academy of Sciences
Submission date: 2022-09-03
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HRA002973.xlsx