Decoding development, aging and activation of neurogenic lineage in human postnatal hippocampus
Release date:
2024-03-07
Description:
The hippocampal neurogenesis throughout life is well studied in mice, but poorly understood in humans. Here, we fully characterized cell compositions and transcriptional signatures of the human hippocampus by single-nucleus RNA sequencing in neonatal, adult, aging and injury states. In the neonatal hippocampus, we reveal gene expression cascades during developmental neurogenesis, report that well-known neuroblast marker genes are also distributed in GABAergic interneurons and identify specific markers of the neurogenic lineage. Primed and active neural stem cell (pNSC and aNSC) acquire distinct molecular alterations and their numbers drop to almost undetectable levels in the adult and aging hippocampus. Importantly, pNSCs and aNSCs reoccur upon stroke-induced injury in the adult human hippocampus. Our findings provide an important resource to delineate development, aging and activation of the human hippocampal neurogenic lineage after birth.
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Organization: State Key Laboratory of Primate Biomedical Research,Kunming University of science technology
Submission date: 2022-08-27
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HRA003049.xlsx