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HRA003240
   HRA003240.xlsx
Title:
Landscape of Potentially Targetable Receptor Tyrosine Kinase Fusions in Diverse Cancers by DNA-based Profiling
Release date:
2024-08-31
Description:
The genomic structures and corresponding partners of RTK fusions differed substantially according to cancer types. Cancer types, such as thyroid cancers, urological cancers and neuroendocrine tumors are selective in the RTK fusions they carry, while others exhibit highly complex spectrums of fusion events. Notably, most RTK genes were promiscuous in terms of the partner genes they recombine with. A large proportion of RTK fusions had one of the breakpoints localized to intergenic regions. Comprehensive genomic profiling revealed differences in co-mutational patterns pre- and post-TKI treatments across various RTK fusions.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA011564
Study type:
Disease Study
Disease name:
solid carcinoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001707
DAC name:
Receptor Tyrosine Kinase Fusions
Contact person:
chen zhanhong
Email:
chzhanh3@mail.sysu.edu.cn
Description:
The genomic structures and corresponding partners of RTK fusions differed substantially according to cancer types. Cancer types, such as thyroid cancers, urological cancers and neuroendocrine tumors are selective in the RTK fusions they carry, while others exhibit highly complex spectrums of fusion events. Notably, most RTK genes were promiscuous in terms of the partner genes they recombine with. A large proportion of RTK fusions had one of the breakpoints localized to intergenic regions. Comprehensive genomic profiling revealed differences in co-mutational patterns pre- and post-TKI treatments across various RTK fusions.
Individuals & samples
Files
Request Data
Submitter:   chen zhanhong / chzhanh3@mail.sysu.edu.cn
Organization:   The Third Affiliated Hospital, Sun Yat-Sen University
Submission date:   2022-08-31
Requests:   -