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HRA003311
   HRA003311.xlsx
Title:
TCR repertoire of OSA
Release date:
2023-02-28
Description:
We investigated the T cell receptor (TCR) repertoires in peripheral blood from 73 patients with OSA, 23 patients without OSA, and 157 healthy individuals. Strikingly, we found an unexpected increase in diversity and clonotypes in the TCR repertoire of OSA. Furthermore, relying on identifying a series of disease-associated clones, we successfully developed a novel indicator termed OSA-TCI to summarize the unique repertoire alteration, which provided 90% of sensitivity and 87% of specificity in distinguishing severe OSA. Furthermore, in rationalization, OSA-TCI was found correlated to AHI, BMI, hemoglobin, N1,N2 percentage of sleep, snoring, smoking and lowest oxygen saturation, but only independently related to AHI (R=0.603) and smoking (R=0.22). Finally, we observed a significant decrease in OSA-TCI in the eight severe patients after home noninvasive ventilation for three months during follow-up, consistently in line with TCR repertoire improvement.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA011227
Study type:
Disease Study
Disease name:
obstructive sleep apnea
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001694
DAC name:
OSA TCR repertoire Group
Contact person:
Li Kai
Email:
trygoing@163.com
Description:
The group of our clinicians, scientists, technicists devoted to ethic approval, patient consent, sample acquisition, laboratory analysis, and bio-information analysis together, hold the reponsibility to release external requests.
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Submitter:   Li Kai / trygoing@163.com
Organization:   The Third People’s Hospital of Chengdu
Submission date:   2022-08-15
Requests:   -