Extrachromosomal Circular DNA Orchestrates Genome Heterogeneity and Outcome in Urothelial Bladder Carcinoma
Release date:
2024-03-02
Description:
we report our pilot CCGA results which we comprehensively characterize the chromosomal DNA, extrachromosomal circular DNA, and transcriptomic alteration landscape in urothelial bladder carcinoma (UBC) of 80 patients by whole-genome/exon sequencing, Circle-seq, single-molecule long-read sequencing technology, and RNA sequencing. Leveraging these large amounts of pair-wise (UBC vs. normal adjacent tissue) and trans-OMICS (genome, circulome, transcriptome) data, we exploit the genome-wide landscape of circular DNA-associated somatic mutations, unbalanced structural variations, oncogene amplification, genomic distributions, structure, and correlations with altered gene expression and clinical outcomes in UBCs.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
HRA003461.xlsx