NGDC - GSA for Human

HRA003588

HRA003588.xlsx

Title:

Integrated Proteogenomic Characterization across Major Histological Types of Pituitary Neuroendocrine Tumors

Release date:

2022-12-09

Description:

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Here, we performed the largest integrative genomics, transcriptomics, proteomics, and phosphoproteomics analysis reported to date in a cohort of 200 PitNET patients. Genomics data indicated that GNAS copy number gain can serve as a reliable diagnostic marker for hyperproliferation of the PIT1 lineage. Proteomics-based classification of PitNETs identified 7 clusters, among which, tumors overexpressing epithelial-mesenchymal transition (EMT) markers clustered into a more invasive subgroup. Further analysis identified potential therapeutic targets, including CDK6, TWIST1, EGFR, and VEGFR2, for different clusters. Immune subtyping to explore the potential for application of immunotherapy in PitNET identified an association between alterations in the JAK1-STAT1-PDL1 axis and immune exhaustion and between changes in the JAK3-STAT6-FOS/JUN axis and immune infiltration.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA012513

Study type:

Disease Study

Disease name:

pituitary adenoma

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC001399

DAC name:

Yao Zhao and Qilin Zhang

Contact person:

Zhang Qilin

Email:

zhangqlhuashan@163.com

Description:

The projects led by Yao Zhao and Qilin Zhang

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