1. Home
  2. Browse
  3. HRA003776
HRA003776
   HRA003776.xlsx
Title:
The Unique Genetic Mutation Characteristics based on Large Panel Next-Generation Sequencing (NGS) Detection in Multiple Primary Lung Cancers (MPLC) Patients
Release date:
2024-02-01
Description:
The 437panel sequencing of 114 nodules in 36 patients found that EGFR accounted for the largest proportion (55.3%), followed by ERBB2 (9.6%), BRAF, and KRAS (8.8%). Fusion target variation is extremely rare (only 2, 1.8%). ERBB2 Y772_A775dup accounted for 73%, KRAS G12C accounted for about 18%, and BRAF V600E accounted only 10%. ARID1A mutations were significantly higher in invasive adenocarcinoma (IA) containing solid/micro-papillary malignant components (P=0.008). The tumor mutation burden (TMB) distribution is low, with a median TMB of 1.1. In addition, 97.2% of patients (35/36) with MPLC had driver gene mutations, and 47% had co-mutations, mainly in IA (45%) and invasive adenocarcinoma (MIA) (37%) nodule. MPLC has a unique genetic mutation characteristic that differs from advanced patients and usually presents with low TMB.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA014216
Study type:
Disease Study
Disease name:
lung cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC002145
DAC name:
panel data
Contact person:
zhang xian
Email:
xian.zhang@geneseeq.com
Description:
Genomic profiling reveals the characteristics of gene mutations in multiple primary lung cancers
Individuals & samples
Files
Request Data
Submitter:   Liang Zhu / liangzhuwsh@163.com
Organization:   Affiliated Hospital of Guangdong Medical University
Submission date:   2023-01-03
Requests:   -