Integrated analysis toolkit for dissecting whole-genome-wide features of cell-free DNA
Release date:
2023-02-25
Description:
Patterns in whole-genome-wide features of cell-free DNA (cfDNA) in human plasma provide a noninvasive diagnostic approach for cancer detection. However, an integrated analysis toolkit for whole-genome-wide features of cfDNA (INAC) is lacking. In this study, these cfDNA whole-genome features, including cfDNA quality control, fragment size, fragment size ratio, copy number variation, transcription start site (TSS) relative coverage, and promoter fragmentation entropy, were estimated by using the INAC toolkit to analyze a collected independent dataset (50 patients with gastric cancer and 50 healthy controls) with ~10x sequence depth.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
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HRA003821.xlsx