We used single-cell RNA sequencing to determine cell type composition of all major human organs and construct a basic scheme for the human cell landscape (HCL). We reveal a single-cell hierarchy for many tissues that has not been well characterized previously. We present a single-cell HCL analysis pipeline that accurately defines human cell types; and exemplify its utility in stem cell biology. Finally, we perform single-cell comparative analysis for human and mouse cell atlas to reveal the conserved genetic networks in the mammalian system.
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HRA003952.xlsx