Non-invasively identifying cancer-specific chromatin accessibility patterns and deciphering the cell type origin of cell-free DNA
Release date:
2023-07-19
Description:
Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA (cfDNA), such as histone modifications and promoter fragmentation. However, the direct link between patterns in the cfDNA and tumor-specific chromatin accessibility has not been experimentally established and its application is limited to the diagnosis of cancer. Therefore, we surveyed plasma cfDNA from 500 individuals including patients with 21 disease types and healthy donors.
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HRA004005.xlsx