YBX1 recognizes m5C modifications of CHD3 mRNA to promote HR repair and enhance platinum resistance of ovarian cancer
Release date:
2025-05-27
Description:
Platinum-based drug chemotherapy causes genetic damage and induces apoptosis in ovarian cancer cells. Enhancing the ability to resist platinum drug-induced DNA damage and apoptotic stress is critical for tumor cells to acquire for drug resistance. our study suggests that YBX1 promotes the development of platinum resistance in ovarian cancer by recognizing m5C modifications and it may be a potential target for reversing drug-resistant therapy.
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Organization: The First Affiliated Hospital of Nanjing Medical University
Submission date: 2023-05-27
Requests: -
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