HRA004878
Title:
Raw RNA sequencing data for CAR-T cells
Release date:
2023-08-13
Description:
We describe an approach that simultaneously addresses the multiple challenges of CAR T as a therapy for solid tumors. The approach massively reprograms CAR T cells by exposing them to stressed target cancer cells which have been exposed to the cell stress inducer disulfiram (DSF) and copper (Cu)(DSF/Cu) plus ionizing irradiation (IR). The reprogrammed CAR T cells acquired early memory-like characteristics, potent cytotoxicity, enhanced in vivo expansion, persistence, and decreased exhaustion.
Data Accessibility:   
Open access
BioProject:
Study type:
Human metagenome
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Submitter:   Wang Xinhui / xwang30@mgh.harvard.edu
Organization:   MGH
Submission date:   2023-06-20