NGDC - GSA for Human

HRA005529

HRA005529.xlsx

Title:

Role of CD8 T cells in chronic airway inflammatory diseases

Release date:

2023-09-18

Description:

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammation of the nose and paranasal sinuses. Severe CRSwNP patients often have comorbid asthma and a high rate of recurrence. Antigen-specific memory lymphocytes seemingly provide a memory that might induce disease relapse when medical and surgical interventions are terminated. Reportedly, a predominant Th2 profile in CRSwNP is also associated with recurrence; a link between CRSwNP and asthma might be a skewing of Th2 response. Whether T lymphocytes in CRSwNP can confer the 'memory' for persistent upper airway inflammation or affecting the lower airway inflammation remain unclear. In this study, we used a combination of technique incluiding scRNA seq, scTCR-seq, bulk RNA-seq and bulk TCR-seq, to reveal the role of CD8 T cells in chronic airway inflammatory diseases.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA015956

Study type:

Disease Study

Disease name:

asthma

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC002798

DAC name:

nasal polyp study group

Contact person:

Lan Feng

Email:

fenglanent@126.com

Description:

a nasal polyp study group

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