NGDC - GSA for Human

HRA006222

HRA006222.xlsx

Title:

Type V Collagen Promotes Lung Adenocarcinoma Metastasis by Regulating Tumor Mechanical Stress and the Implication for Prognosis and Therapeutic Strategies

Release date:

2025-11-30

Description:

Mechanical stress, simulated by matrix application, enhanced LUAD cell migration and invasion, correlating with ECM alterations and EMT pathway activation. Machine learning-based SVM_Score predicted LUAD patient prognosis across multiple datasets, revealing its robust prognostic capabilities. Lower SVM_Scores were associated with worse survival outcomes, increased cancer-related pathways, higher Tumor Mutation Burden, and altered immune microenvironment characteristics. SVM_Score was also linked to myofibroblast-secreted COL5A1, a key marker for mechanical stress. Patient tissues with low SVM_Scores exhibited higher COL5A1 expression, enhanced EMT propensity, and increased internal mechanical stress. Sorafenib, by inhibiting COL5A1 secretion, attenuated the pro-tumor effects of myofibroblasts, rendering LUAD cells more sensitive to chemotherapy.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA021695

Study type:

Disease Study

Disease name:

non-small cell lung carcinoma

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC003417

DAC name:

Tianjin Lung Cancer Institute

Contact person:

Liu Hongyu

Email:

liuhongyu123@hotmail.com

Description:

Tianjin Lung Cancer Institute Data Management Board

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