Precision Induction Therapy for Inoperable NSCLC in Stage III Disease: A Phase II Umbrella Clinical Trial
Release date:
2025-01-26
Description:
The objective is to assess the efficacy and safety of precision induction therapies in patients with unresectable stage III NSCLC selected based on tumor PD-L1 expression. Patients were stratified into groups receiving Sintilimab monotherapy, Sintilimab plus IBI305, or Sintilimab combined with chemotherapy. Multi-disciplinary team (MDT) to discuss whether surgery was performed 3-4 weeks after last dose of therapy. Surgery was performed 4-6 weeks after last dose of induction therapy. RNA-seq and WES were performed at baseline, and the tumor samples were also collected for RNA-seq after surgery. Based on bioinformatics analysis, we want to find better biomarker to stratified patients and explore optimized regimens for unresectable stage III NSCLC.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
The objective is to assess the efficacy and safety of precision induction therapies in patients with unresectable stage III NSCLC selected based on tumor PD-L1 expression. Patients were stratified into groups receiving Sintilimab monotherapy, Sintilimab plus IBI305, or Sintilimab combined with chemotherapy. Multi-disciplinary team (MDT) to discuss whether surgery was performed 3-4 weeks after last dose of therapy. Surgery was performed 4-6 weeks after last dose of induction therapy. This data set includes RNA-seq and WES data. The tissue collected from baseline patietns were send for RNA-seq and WES, and the tumor samples collected after surgery were send for RNA-seq only.
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
HRA006345.xlsx