Determinants of neoadjuvant response and resistance in advanced clear cell renal cell carcinoma
Release date:
2025-08-19
Description:
With immunotherapy-based combination (ICB) has been recommended as first-line treatment for advanced RCC, Labbate et al. initially reported a case of complete response of an extensive vena cava tumor thrombus with neoadjuvant immunotherapy. Though the safety and feasibility has been confirmed by following studies, the evidence was based on case report and series. Due to high objective response rate of ICB than TKI in advanced RCC, we hypothesized that the ICB would yield a higher reduction in level of inferior vena cave tumor thrombus (IVC-TT). This Phase 2 pilot study evaluated the efficacy and safety of neoadjuvant toripalimab plus axitinib for RCC with IVC-TT.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
With immunotherapy-based combination (ICB) has been recommended as first-line treatment for advanced RCC, Labbate et al. initially reported a case of complete response of an extensive vena cava tumor thrombus with neoadjuvant immunotherapy. Though the safety and feasibility has been confirmed by following studies, the evidence was based on case report and series. Due to high objective response rate of ICB than TKI in advanced RCC, we hypothesized that the ICB would yield a higher reduction in level of inferior vena cave tumor thrombus (IVC-TT). This Phase 2 pilot study evaluated the efficacy and safety of neoadjuvant toripalimab plus axitinib for RCC with IVC-TT.
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
HRA006643.xlsx