Endothelial Progenitor Cells Control Remodeling of Uterine Spiral Arteries for the Establishment of Utero-placental Circulation
Release date:
2024-03-27
Description:
Placental ischemia, resulting from inadequate remodeling of uterine spiral arteries, is a factor in the development of preeclampsia. However, the effect of endothelial progenitor cells that plays a role in the vascular injury-repair program is largely unexplored during remodeling. Here, we observe that preeclampsia-afflicted uterine spiral arteries exhibit transition to a synthetic phenotype in vascular smooth muscle cells and characterize the regulatory axis in endothelial progenitor cells during remodeling in human decidua basalis. Our findings suggest that the impaired functionality of endothelial progenitor cells contributes to the narrowing of remodeled uterine spiral arteries, leading to reduced utero-placental perfusion,a mechanism that holds promise in elucidating the pathogenesis of preeclampsia.
Organization: Chongqing Health Center for Women and Children
Submission date: 2024-03-25
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