Small cell lung cancer (SCLC), a highly aggressive malignancy that accounts for 15% of all lung cancer cases and kills 270,000 patients each year worldwide. Loss-of-function mutations in tumor suppressors represents a feature of small cell lung cancer (SCLC), but high frequency gain-of-function alterations in oncogenes have rarely been reported. In this study, we conducted single cell RNA-seq in small cell lung cancer.
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Small cell lung cancer (SCLC), a highly aggressive malignancy that accounts for 15% of all lung cancer cases and kills 270,000 patients each year worldwide. Loss-of-function mutations in tumor suppressors represents a feature of small cell lung cancer (SCLC), but high frequency gain-of-function alterations in oncogenes have rarely been reported. In this study, we conducted scRNA-seq, bulk RNA-seq, 16S rRNA gene-sequencing, and WES in Small cell lung cancer.
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