NGDC - GSA for Human

HRA007214

HRA007214.xlsx

Title:

Human receptive endometrial organoid for deciphering the implantation window

Release date:

2025-12-28

Description:

Human endometrial receptivity determines the success of pregnancy; however, in vivo studies of its features and regulation are particularly challenging due to ethical restriction. Recently, developed human endometrial organoids present a powerful model to dissect this complexity. Here, we established specific human window-of-implantation (WOI) endometrial organoids that can mimic the in vivo receptive endometrium. It not only structurally consists of glands and stroma but also shows similar cell types compared with the in vivo endometrium at the single-cell level. The WOI endometrial organoid also showed hormone response, secretion function and special characteristics of the implantation window, such as decidualization, ECM remodeling, pinopode generation, angiogenesis and immunoregulation. The model also clearly resolved the process of proliferation-secretory transformation, ciliary epithelium differentiation and EMT during the implantation window in vitro.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA015573

Study type:

Organoids

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC002392

DAC name:

NRCARTRG

Contact person:

Zhao Rusong

Email:

Ashley_rs@163.com

Description:

Data Administration Committee of National Research Center for Assisted Reproductive Technology and Reproductive Genetics

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