Single-cell transcriptomic analysis revealed the tumor-associated microenvironment of papillary thyroid carcinoma with metastasis
Release date:
2024-10-12
Description:
Papillary thyroid cancer (PTC) is frequently associated with inflammation and lymph node (LN) metastasis. Single-cell RNA sequencing (scRNA-seq) can uncover rare sub-populations of cells and investigate the diverse functions inside tissue microenvironments. In this study, we used scRNA-seq analysis to examine the differences in macrophages, dendritic cells (DCs), and T cells between a metastatic PTC (PTC-M) and its adjacent normal tissues, as well as a PTC tumor without metastasis. Our findings revealed the presence of heterogeneity in these immune cell populations in the PTC-M sample, suggesting that immunosuppressive components play a role in the development and metastasis of PTC.
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Submitter: Liu Qingbin / jnmclqb@mail.jnmc.edu.cn
Organization: Jining NO.1 People's Hospital, Jining Medical University
Submission date: 2024-06-26
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HRA007797.xlsx