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HRA007803
   HRA007803.xlsx
Title:
Synthetic lethality of CDK4/6 and CDK7 inhibitors in TNBC
Release date:
2024-06-28
Description:
We present a novel approach to overcoming the intrinsic resistance of TNBC to CDK4/6 inhibitors by targeting transcription regulator CDK7. This dual inhibition strategy induces a synthetic lethality effect in various TNBC models, both in vitro and in vivo, marking a pioneering therapeutic avenue for TNBC.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA027430
Study type:
Cell line related study
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC004297
DAC name:
CDK4/6 and CDK7 in TNBC
Contact person:
Guo Xiaomao
Email:
guoxm1800@163.com
Description:
We present a novel approach to overcoming the intrinsic resistance of TNBC to CDK4/6 inhibitors by targeting transcription regulator CDK7. This dual inhibition strategy induces a synthetic lethality effect in various TNBC models, both in vitro and in vivo, marking a pioneering therapeutic avenue for TNBC.
Individuals & samples
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Submitter:   Guo Xiaomao / guoxm1800@163.com
Organization:   Fudan University Shanghai Cancer Center
Submission date:   2024-06-26
Requests:   -