Nanopore sequencing-based genotyping corroborated the association between CYP2D6 function and susceptibility to anxiety and depression
Release date:
2024-07-04
Description:
CYP2D6 activity has been inconsistently associated with anxious and depressive personality traits. The inconsistency may stem from limitations of targeted genotyping, employed in most previous studies, leading to undetected errors in metabolic classification. Using a nanopore sequencing-based method, we comprehensively genotyped CYP2D6 alleles in a small cohort of 96 Malaysians and re-examined the relationship between CYP2D6 activity and susceptibility to anxiety and depression
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HRA007810.xlsx