A spatially resolved atlas of gastric cancer characterises a lymphocyte aggregated region
Release date:
2025-12-03
Description:
The tumour microenvironment (TME) is a focal point in cancer immunotherapy: its cellular composition and spatial organisation, especially the distribution of lymphocytes, can affect the clinical outcomes of cancer patients. In addition, the function of a cell differs depending on its spatial location and interaction with neighbouring cells. Here, by integrating single-cell transcriptomics with spatial transcriptomics, we survey how the spatial distribution of different cell types varies across diverse histological regions of gastric cancer. Our findings advance the understanding of TLSs in contributing to anti-tumorigenic immunity in a spatially resolved context, which could be further leveraged as a predictive marker for immunotherapy response.
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The tumour microenvironment (TME) is a focal point in cancer immunotherapy: its cellular composition and spatial organisation, especially the distribution of lymphocytes, can affect the clinical outcomes of cancer patients. In addition, the function of a cell differs depending on its spatial location and interaction with neighbouring cells. Here, by integrating single-cell transcriptomics with spatial transcriptomics, we survey how the spatial distribution of different cell types varies across diverse histological regions of gastric cancer. Our findings advance the understanding of TLSs in contributing to anti-tumorigenic immunity in a spatially resolved context, which could be further leveraged as a predictive marker for immunotherapy response.
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HRA007814.xlsx