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HRA007830
   HRA007830.xlsx
Title:
Hypoxia modulates chromatin accessibility in chondrocytes.
Release date:
2025-07-01
Description:
Chromatin accessibility in chondrocytes under normoxia and hypoxia was analyzedusing Assay for Transposase-Accessible Chromatin with highthroughput sequencing(ATAC.Seg)to identify potential regulatory elements.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA027588
Study type:
Disease Study
Disease name:
osteoarthritis
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC004321
DAC name:
Chondrocytes reprogram chromatin
Contact person:
Shen Shuying
Email:
shenshuying@zju.edu.cn
Description:
Maintaining chondrocyte homeostasis is crucial for the effective treatment of osteoarthritis (OA). Chondrocytes reside in a hypoxic environment under physiological conditions. This study examined the association between epigenetics and chondrocyte homeostasis and observed significant alterations in the histone acetylation in chondrocytes under hypoxic conditions. A key enhancer element was found to regulate CADM1-AS1, which plays a critical role in maintaining cartilage homeostasis. Further mechanistic investigations revealed that CADM1-AS1 recruits histone deacetylase complexes to suppress the transcriptional activation of NOS2, thereby affecting chondrocyte amino acid metabolism in chondrocytes. Conditional knockout of CADM1-AS1 in chondrocytes accelerated OA development in mice.
Individuals & samples
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Submitter:   Shen Shuying / shenshuying@zju.edu.cn
Organization:   Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Submission date:   2024-07-01
Requests:   -