NOTCH1 mutation predicts better clinical survival benefit of tislelizumab in second-line esophageal squamous cell carcinoma: a RATIONALE-302 study biomarker analysis
Release date:
2024-08-09
Description:
Retrospectively collected adjacent and tumor samples from 30 esophageal cancer patients were subjected to whole-exome sequencing. Additionally, multiplex immunofluorescence staining was performed on patient tissue sections. The study found that, compared to patients with wild-type NOTCH1, those with NOTCH1-mutant esophageal cancer exhibited significantly lower proportions of B cells and neutrophils in their tumor tissues.
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