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HRA008254
   HRA008254.xlsx
Title:
Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma
Release date:
2025-06-07
Description:
Alpha-fetoprotein (AFP) is a widely used canonical biomarker for the incidence or recurrence of hepatocellular carcinoma (HCC). AFP-positive HCC (APHCC) has been intensively investigated; however, the microenvironmental characteristics of AFP-negative HCC (ANHCC) remain to be deciphered. We not only uncovered a previously unrecognized AR-mediated hyperactive arachidonic acid microenvironment in ANHCC, but also revealed AR-11,12-EET-EGFR axis-induced angiogenesis, providing a strategy for combined androgen receptor inhibitor with anti-angiogenic blockade for ANHCC intervention.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA028990
Study type:
Disease Study
Disease name:
hepatocellular carcinoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC004531
DAC name:
AFP_HCC
Contact person:
Kuang Ming
Email:
kuangm@mail.sysu.edu.cn
Description:
Alpha-fetoprotein (AFP) is a widely used canonical biomarker for the incidence or recurrence of hepatocellular carcinoma (HCC). AFP-positive HCC (APHCC) has been intensively investigated; however, the genomic, transcriptomic and microenvironmental characteristics of AFP-negative HCC (ANHCC) remain to be deciphered.
Individuals & samples
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Submitter:   Kuang Ming / kuangm@mail.sysu.edu.cn
Organization:   The First Affiliated Hospital, Sun Yat-sen University
Submission date:   2024-08-12
Requests:   1