NGDC - GSA for Human

HRA009064

HRA009064.xlsx

Title:

Single-cell transcriptome profiling elucidates the cellular determinants of immunotherapy response in gastric cancer peritoneal metastasis

Release date:

2024-11-04

Description:

The cohorts were derived from a phase II study with patients with GCPM treated with injectable paclitaxel (albumin-binding) via intraperitoneal perfusion combined with intravenous sindilimab, S-1 and Oxaliplatin (GC-IP001 study; https://www.chictr.org.cn/showproj.html?proj=191640). scRNA-seq was performed on 21 surgical resection and biopsy GCPM samples, 7 primary GC samples, 5 peritumoral gastric normal (GN) samples and 4 peripheral blood mononuclear cell (PBMC) samples. The samples were derived from 19 GC patients, with 14 cases treated with ICB therapy, of which 5 patients exhibited partial response (PR) after treatment, 4 patients exhibited stable disease (SD), and 5 patients exhibited progressive disease (PD). 4 patients treated by ICB had paired samples of GN, GC, GCPM and PBMC, and 1 patient treated by ICB had paired samples of GC and GCPM. The samples were sequenced using the Droplet 10x platforms to fetch scRNA-seq data.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA031633

Study type:

Disease Study

Disease name:

stomach cancer

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC004912

DAC name:

DAC of GCPM project

Contact person:

Luo Huiyan

Email:

luohy@sysucc.org.cn

Description:

Users who want to use this data should submit applications in GSA human database.

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