Hormonal Influence on Sexual Dimorphism in Keratoconus: Insights from Transcriptome Analysis
Release date:
2026-01-31
Description:
Keratoconus (KC) is a degenerative corneal disorder characterized by asymmetric thinning and vision impairment, with its incidence and progression influenced by sex-specific factors. Through whole transcriptome sequencing of corneal samples from male and female KC patients as well as healthy controls, we identified genes exhibiting sex-biased expression and distinct pathways associated with oxidative phosphorylation, endocrine resistance, and axon guidance.
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HRA009568.xlsx