Elevated Nonhomologous End-Joining by AATF Enables Efficient DNA Damage Repair and Therapeutic Resistance in Glioblastoma
Release date:
2024-12-16
Description:
Glioblastoma (GBM) is a lethal primary brain tumor with limited response to radiotherapy in part due to GBM stem cells (GSCs). Here, we show that GSCs repair DNA damage through non-homologous end-joining (NHEJ) repair to resist radiotherapy.
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Individuals & samples
Files
Submitter: Man Jianghong / jhman@ncba.ac.cn
Organization: National Center of Biomedical Analysis
Submission date: 2024-12-12
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HRA009680.xlsx