PARylation-mediated stabilization of AFF1 protein promotes transcriptional restart in response to DNA damage
Release date:
2025-07-30
Description:
Our findings expand the role of PARP1 to include the transcriptional recovery phase in DDR and suggest that targeting the PARSTA pathway could be beneficial in diseases characterized by hyperactive PARP1 and elevated levels of AFF1.
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Individuals & samples
Files
Submitter: lu hua song / huasong_lu@zju.edu.cn
Organization: Zhejiang University
Submission date: 2025-01-15
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HRA010143.xlsx