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HRA011455
   HRA011455.xlsx
Title:
Co-condensation between transcription factor and chromatin remodeler selectively modulates gene expression
Release date:
2025-11-14
Description:
Gene transcription is a fundamental process that plays critical roles in regulating cellular functionality and organismal development. The activation of gene transcription is a highly coordinated event that necessitates the orchestrated engagement of various transcription factors (TFs) and the transcription apparatus to access DNA at specific gene promoters and enhancers. The DNA accessibility, the most important prerequisite for the initiation of gene transcription, is produced by chromatin remodelers, which utilize ATP to reposition or evict nucleosomes from the DNA. Although it is well established that chromatin remodelers maintain an accessible chromatin environment, the mechanism how they are directed to specific genomic regions are not fully understood. Here we find that IDR-mediated selective co-condensation between TFs and chromatin remodeler represents a mechanism for specific gene activation.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA040009
Study type:
Cell line related study
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC005972
DAC name:
Data Administrator Organization
Contact person:
Lu Yi
Email:
yilu_tju@tongji.edu.cn
Description:
The data administrator convenes the DAC members to jointly review the data application and feeds back the review result in the system.
Individuals & samples
Files
Request Data
Submitter:   Lu Yi / yilu_tju@tongji.edu.cn
Organization:   Tongji University
Submission date:   2025-05-11
Requests:   -