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HRA011646
   HRA011646.xlsx
Title:
A single-cell RNA-seq dataset of synovial fluid from rheumatoid arthritis treated with TNF/JAK inhibitor
Release date:
2025-05-28
Description:
We present a comprehensive scRNA-seq analysis of synovial fluid samples of RA patients treated with tofacitinib or adalimumab, both pre- and post-treatment. Following stringent quality control, we analyzed 106,506 high-quality cells, providing an in-depth characterization of cell composition, molecular signaling pathways, and functional properties. This rich dataset offers a valuable resource to address diverse research questions, from uncovering the mechanisms of action of TNF and JAK inhibitors, to identifying novel therapeutic targets for RA, and advancing our understanding of the pathogenesis of inflammatory diseases.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA024344
Study type:
Disease Study
Disease name:
rheumatoid arthritis
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001325
DAC name:
rheumatoid arthritis
Contact person:
Xu Heng
Email:
xuheng81916@scu.edu.cn
Description:
A rheumatoid arthritis population with TNF or JAK inhibitors treatment
Individuals & samples
Files
Request Data
Submitter:   Xu Heng / xuheng81916@scu.edu.cn
Organization:   Sichuan University
Submission date:   2025-05-24
Requests:   5