Systematic analysis of functional genetic and epigenetic variants in colorectal cancer
Release date:
2026-02-21
Description:
We developed and applied two high-throughput techniques, SNP-STARR-seq and Methyl-STARR-seq, to systematically evaluate the influence of 30,790 non-coding SNPs and over 134,000 CpG sites on enhancer activity in cells sourced from primary and metastatic colorectal cancer. Additionally, we generated two independent knockout HCT116 cell lines using CRISPR/Cas9, each with a short fragment (89 bp and 136 bp, respectively) spanning the target SNP rs6061231 removed from the genome.
Note: HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client) or Asepra Command Line.
Individuals & samples
Files
Submitter: YAN JIAN / jian.yan@nwu.edu.cn
Organization: Northwest University
Submission date: 2025-07-10
Aspera Command Line
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
Note: HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client) or Asepra Command Line.
HRA012284.xlsx