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HRA013372
   HRA013372.xlsx
Title:
Study on the mechanism of eosinophils in eosinophilic granulomatosis with polyangiitis
Release date:
2025-11-12
Description:
Churg-Strauss syndrome, now known as eosinophilic granulomatosis with polyangiitis (EGPA), is a life-threatening vasculitis that is often misdiagnosed as asthma in its early stages, and its pathogenesis has not been fully elucidated. We performed scRNA-seq comparing blood, bronchoalveolar lavage fluid (BALF) and bronchi biopsies from control, asthma and EGPA subjects. We discover that an inflammatory neutrophil subset, which highly expresses interferon stimulated genes, IL1B and TNFSF13B (BAFF), is enriched in bronchi biopsies in EGPA. This corresponded with increased FCRL4+ memory B cells and anti-neutrophil autoantibodies in the patients. In pre-clinical murine models, we show that blocking IGF-1 suppressed eosinophil infiltration and ameliorated asthma and EGPA severities. In summary, we identify pathogenic mechanisms and suggest that IGF-1 is a candidate therapeutic target for Asthma and EGPA.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA023383
Study type:
Cohort Study
Disease name:
Churg-Strauss syndrome
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC003678
DAC name:
Asthma and EGPA
Contact person:
Zhang Qingling
Email:
zqling@gzhmu.edu.cn
Description:
Responsible for reviewing and authorizing requests for access to controlled data in accordance with the consent form and/or national research ethics provisions
Individuals & samples
Files
Request Data
Submitter:   Zhang Qingling / zqling@gzhmu.edu.cn
Organization:   National Respiratory Medicine Center/State Key Laboratory of Respiratory Disease/Guangzhou Institute of Respiratory Health/The First Affiliated Hospital, Guangzhou Medical University
Submission date:   2023-12-13
Requests:   -