METTL3 and METTL14 determine human neural fate specifications
Release date:
2025-11-24
Description:
Mechanistically, METTL3 is enriched in gene loci essential for neurogenesis and chromatin remodeling in human NPCs, thereby promoting chromatin accessibility at these sites. Importantly, forced expression of BRM, a catalytic component of chromatin-remodeling BAF complex, in METTL3-deficient hESCs rescues the defects in neural fate specifications caused by METTL3 loss. Our study systematically defines the essential requirement of METTL3/ METTL14 in ensuring the fidelity and neuronal specification of human NPCs, and underscores the coordination among distinct epigenetic regulators in neural development.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
Organization: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Submission date: 2025-10-16
Requests: -
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