scMulti-omics Reveals that Bortezomib Pre-treatment Enhances the Anti-tumor Efficacy of CD19 CAR T Cells
Release date:
2026-01-25
Description:
Our previous data showed that CAR T cells with high proteasome activity exhibit reduced therapeutic efficacy due to their tendency to undergo terminal differentiation. And pre-treatment of CAR T cells during manufacturing with a low dose of bortezomib significantly improved their anti-tumor efficacy. To investigate how short-term bortezomib treatment prolongs the survival of leukemia-bearing mice, we performed single-cell multi-omics (scMulti-omics) analysis.
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