Osimertinib with or without savolitinib as first-line treatment for MET-aberrant, EGFR-mutant NSCLC: randomized phase 2 trial (FLOWERS)
Release date:
2025-10-28
Description:
Poor response to EGFR inhibitor alone is seen in advanced non-small cell lung cancer with EGFR mutations and de novo MET aberrations. This Phase 2 randomized trial shows promising antitumor activity and good safety in such patients treated with first-line osimertinib plus savolitinib.
Organization: Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China
Submission date: 2025-10-28
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HRA014210.xlsx