Functional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Release date:
2026-04-07
Description:
Pericyte loss is an early event in diabetic retinopathy, but the underlying mechanisms remain unclear. Single-cell RNA sequencing of retinal cells identified a PTTG1-high pericyte subpopulation that was enriched in diabetic mice. Integrated transcriptomic and metabolomic analyses showed that PTTG1 silencing reprogrammed cellular metabolism, altering glycolytic flux and reducing oxidative stress.
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Individuals & samples
Files
Submitter: Yan Biao / yanbiaolab@outlook.com
Organization: Shanghai General Hospital
Submission date: 2026-03-31
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HRA017642.xlsx