Glucose-induced histone lactylation confers metformin resistance in colorectal cancer stem cells
Release date:
2026-04-24
Description:
Metformin has been proposed as a therapy for cancer, but many reports are showing limited efficacy. Here, the authors show that in high-glucose conditions, histone lactylation induces fatty acid uptake leading to metformin resistance in colorectal cancer stem cells
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Individuals & samples
Files
Submitter: Shi Hanping / shihp@ccmu.edu.cn
Organization: Beijing Shijitan Hospital, Capital Medical University
Submission date: 2026-04-21
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HRA018092.xlsx