DAC NO.: HDAC005761
DAC name: Metagenome of sputum and fecal
Contact person: Shen Yifei
URL: https://academic.oup.com/bib/article/23/6/bbac450/6762744?login=false
Description: A total of 68 patients with confirmed SARS-CoV-2 infection were included in the study, divided into two subgroups: patients with PF and patients without PF. Metagenomic sequencing of sputum and fecal specimens was performed to profile respiratory and intestinal microbiota. Peripheral blood mononuclear cells (PBMCs) were collected for transcriptome sequencing, and gene expression data were analyzed using Gene Set Enrichment Analysis to identify pathway alterations associated with PF. Spearman correlation analysis was used to examine relationships between clinical indicators and microbial composition. A random forest classifier was developed to predict PF risk based on integrated respiratory-intestinal microbiota profiles as well as clinical indicators.
