| Identifier | PRJCA025727 |
| Title | MeRIP-seq of growth hormone-secreting pituitary neuroendocrine tumor |
| Project data type |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
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| Organism |
Rattus norvegicus
Homo sapiens
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| Description | Growth hormone-secreting pituitary adenomas account for approximately 10% of endocrine pituitary tumors and are pathologically classified into densely granulated adenomas (DGGH) and sparsely granulated adenomas (SGGH). m6A has been reported to play an important role in tumorigenesis and development, but its potential role in the pathogenesis of these two subtypes has not yet been thoroughly investigated. Consequently, we performed MeRIP-seq analysis of pituitary adenomas and the GH3 cell line. We observed that the expression of FTO was significantly increased in SGGH, leading to a reduction in m6A modification and a disruption of desmosome organization. |
| Sample scope | Multispecies |
| Release date | 2026-04-29 |
| Publication |
| PubMed ID |
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Journal |
Doi |
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| Consortium |
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| Submission |
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Zhixiang Zuo
Sun Yat-sen University Cancer Center
|
| zuozhx@sysucc.org.cn |
| 2024-04-29 |
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