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Home Species Homo sapiens
Cervical Cancer

Basic Information

Homo sapiens / Cervical Cancer
Species: Human
Category: Human Cancer Studies
Description: Cervical cancer is one of the most common gynecological cancers in low- and middle-income countries, contributing to 10–15% of cancer death in females worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus. Even if cervical HPV infection is incredibly common, cervical cancer is relatively rare. The frequency of cervical cancer after treatment for dysplasia is lower than 1% and mortality is less than 0.5%. The prevention of cervical cancer includes screening and vaccination.

Gene Summary

mRNA

ICG00153-48
CHCHD1 SRSF9 TMBIM6
ICG00153-100
EEF1A1 GAPDH

Small nucleolar RNAs

ICG00153-49
U6

Long non-coding RNA

ICG00153-49
lncRNA RP11-204K16.1 XLOC_012542

Studies (3)

ICG00153-100

Cervical Cancer
Cervical Intraepithelial Neoplasia
Histologies
Cancer Studies

Internal Control Genes

Gene Symbol Gene Model Application Scenario Accession Number Primers(5' - 3')
(Forward/Reverse)		 Size (bp) Annealing Temperature Detection
EEF1A1 Elongation Factor
Normal Cervical Tissues
Cervical Cancer Tissues
Intraepithelial Neoplasia Tissues
Tumor-Normal Pairs
 NM_001402
F: TGCGGTGGGTGTCATCAAA
R: AAGAGTGGGGTGGCAGGTATTG
 123 63 SYBR
GAPDH Glyceraldehyde-3-Phosphate Dehydrogenase
Normal Cervical Tissues
Cervical Cancer Tissues
Intraepithelial Neoplasia Tissues
Tumor-Normal Pairs
 NM-002046
F: GACAGTCAGCCGCATCTTCT
R: TTAAAAGCAGCCCTGGTGAC
 127 63 SYBR

Molecular Types:

mRNA

Evaluation Methods

geNorm
NormFinder

Contact

Name: Xing Xie
Email: xiex@mail.hz.zj.cn
Institution: Women’s Reproductive Health Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Reference

Identification of suitable reference genes for measurement of gene expression in human cervical tissues.
Shen Y, Li Y, Ye F, Wang F, Lu W, Xie X.
Analytical biochemistry. 2010-06-19

ICG00153-48

Cervical Cancer
Hypoxia Stress
Cell Types
Cancer Studies

Internal Control Genes

Gene Symbol Gene Model Application Scenario Accession Number Primers(5' - 3')
(Forward/Reverse)		 Size (bp) Annealing Temperature Detection
CHCHD1 Coiled-Coil-Helix-Coiled Coil-Helix Domain
Cervical Cancer
Hela Cell Line
Sw756 Cell Line
C-33-A Cell Line
C-4I Cell Line
Me-180 Cell Line
Ht-3 Cell Line
Siha Cell Line
Caski Cell Line
 NM_203298.2
F: Hs00415053_g1
R: Hs00415053_g1
 98 60 TaqMan
SRSF9 Serine And Arginine Rich Splicing Factor
Cervical Cancer
Hela Cell Line
Sw756 Cell Line
C-33-A Cell Line
C-4I Cell Line
Me-180 Cell Line
Ht-3 Cell Line
Siha Cell Line
Caski Cell Line
 NM_003769.2
F: Hs01596548_g1
R: Hs01596548_g1
 117 60 TaqMan
TMBIM6 Transmembrane
Cervical Cancer
Hela Cell Line
Sw756 Cell Line
C-33-A Cell Line
C-4I Cell Line
Me-180 Cell Line
Ht-3 Cell Line
Siha Cell Line
Caski Cell Line
 NM_003217.2
F: Hs00162661_m1
R: Hs00162661_m1
 87 60 TaqMan

Molecular Types:

mRNA

Evaluation Methods

geNorm
NormFinder

Contact

Name: Heidi Lyng
Email: heidi.lyng@rr-research.no
Institution: Department of Radiation Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

Reference

Identification and Validation of Reference Genes for RT-qPCR Studies of Hypoxia in Squamous Cervical Cancer Patients.
Fjeldbo CS, Aarnes EK, Malinen E, Kristensen GB, Lyng H.
PloS one. 2016-05-31

ICG00153-49

Cervical Cancer
Cancer Studies

Internal Control Genes

Gene Symbol Gene Model Application Scenario Accession Number Primers(5' - 3')
(Forward/Reverse)		 Size (bp) Annealing Temperature Detection
lncRNA RP11-204K16.1 LncRNA
Primary Fibroblasts
Crl-2708 Cell Line
Hpv-Positive Carcinoma
Hela (Ccl2) Cell Line
Siha (Htb-35) Cell Line
Ms751 Cell Line
Hpv-Negative Carcinoma
C33A (Htb-31) Cell Line
Helacell Line
Siha Cell Line
Ms751 Cell Line
C33A Cell Line
Crl-2614 Cell Line
Hpv-16 E6 Cell Line
Hpv-16 E7 Cell Line
 -
F: CCCAAGATGCTGAAAGGAAAGAAAG
R: CTCAAACAGGGGATTCACCACTTC
 - 58.8 SYBR
XLOC_012542 LncRNA
Primary Fibroblasts
Crl-2708 Cell Line
Hpv-Positive Carcinoma
Hela (Ccl2) Cell Line
Siha (Htb-35) Cell Line
Ms751 Cell Line
Hpv-Negative Carcinoma
C33A (Htb-31) Cell Line
Helacell Line
Siha Cell Line
Ms751 Cell Line
C33A Cell Line
Crl-2614 Cell Line
Hpv-16 E6 Cell Line
Hpv-16 E7 Cell Line
 -
F: GTGATTCAACAACCCTCCATCTCTG
R: TCACACACACCCATCCCATCC
 - 58.8 SYBR
U6 SnoRNA
Primary Fibroblasts
Crl-2708 Cell Line
Hpv-Positive Carcinoma
Hela (Ccl2) Cell Line
Siha (Htb-35) Cell Line
Ms751 Cell Line
Hpv-Negative Carcinoma
C33A (Htb-31) Cell Line
Helacell Line
Siha Cell Line
Ms751 Cell Line
C33A Cell Line
Crl-2614 Cell Line
Hpv-16 E6 Cell Line
Hpv-16 E7 Cell Line
 -
F: CTCGCTTCGGCAGCACATATAC
R: GGAACGCTTCACGAATTTGC
 - 62.5 SYBR

Molecular Types:

Long non-coding RNA

Evaluation Methods

geNorm
NormFinder
BestKeeper

Contact

Name: Tawin Iempridee
Email: tawin@nanotec.or.th
Institution: National Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, Thailand

Reference

Identification of reference genes and miRNAs for qRT-PCR in human esophageal squamous cell carcinoma.
Chen L, Jin Y, Wang L, Sun F, Yang X, Shi M, Zhan C, Shi Y, Wang Q.
Medical oncology (Northwood, London, England). 2016-11-26