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Home Species Homo sapiens
Ovarian Cancer

Basic Information

Homo sapiens / Ovarian Cancer
Species: Human
Category: Human Cancer Studies
Description: Ovarian cancer is the most lethal gynecologic malignancy. Ovarian cancer encompasses a collection of neoplasms with distinct clinicopathological and molecular features and prognosis. Surgery and chemotherapy are the primary treatments for ovarian cancer; however, patients often succumb to recurrence with chemotherapeutic resistance within several years after the initial treatment.

Gene Summary

mRNA

ICG00153-10
GUSB PPIA TBP
ICG00153-30
18S RNA
ICG00153-90
RPL13A

Studies (3)

ICG00153-10

Serous Ovarian Cancer
Cancer Studies

Internal Control Genes

Gene Symbol Gene Model Application Scenario Accession Number Primers(5' - 3')
(Forward/Reverse)		 Size (bp) Annealing Temperature Detection
GUSB Glucuronidase
Serous Ovarian Cancer Tissues
Normal Ovarian Epithelium
Specimens
Tumor-Normal Pairs
 NM_000181
F: AGCCAGTTCCTCATCAATGG
R: GGTAGTGGCTGGTACGGAAA
 160 60 - 63 SYBR
PPIA Peptidylprolyl Isomerase
Serous Ovarian Cancer Tissues
Normal Ovarian Epithelium
Specimens
Tumor-Normal Pairs
 NM_021130
F: AGACAAGGTCCCAAAGAC
R: ACCACCCTGACACATAAA
 118 61 - 63 SYBR
TBP TATA-binding Protein
Serous Ovarian Cancer Tissues
Normal Ovarian Epithelium
Specimens
Tumor-Normal Pairs
 NM_003194
F: TGCACAGGAGCCAAGAGTGAA
R: CACATCACAGCTCCCCACCA
 132 62 - 63 SYBR

Molecular Types:

mRNA

Evaluation Methods

geNorm
NormFinder

Contact

Name: Xing Xie
Email: xiex@mail.hz.zj.cn
Institution: Reproductive Health Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women Hospital, School of Medicine, Zhejiang University, Xueshi Rd. No. 2,Hangzhou 310006, China

Reference

Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction.
Li YL, Ye F, Hu Y, Lu WG, Xie X.
Analytical biochemistry. 2009-07-19

ICG00153-30

Ovarian Cancer
Hypoxia Stress
Cancer Studies

Internal Control Genes

Gene Symbol Gene Model Application Scenario Accession Number Primers(5' - 3')
(Forward/Reverse)		 Size (bp) Annealing Temperature Detection
18S RNA 18S Ribosomal RNA
Ovarian Cancer
Caov3 Cell Line
Ovcar3 Cell Line
Skov3 Cell Line
Hypoxic Environmental Exposure
 NR_003286.4
F: CAGATCAAAACCAACCCG
R: GCCCTATCAACTTTCGATGG
 152 60 SYBR

Molecular Types:

mRNA

Evaluation Methods

geNorm
NormFinder

Contact

Name: Jie Shen
Email: drshenjie@126.com
Institution: Department of Orthopaedics, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, People’s Republic of China

Reference

Identification and Validation of Reference Genes Selection in Ovarian Cancer Exposed to Hypoxia.
Yan W, Xie M, Li R, Hu H, Tang B, Shen J.
OncoTargets and therapy. 2020-07-28

ICG00153-90

Ovarian Cancer
Cell Types
Cancer Studies

Internal Control Genes

Gene Symbol Gene Model Application Scenario Accession Number Primers(5' - 3')
(Forward/Reverse)		 Size (bp) Annealing Temperature Detection
RPL13A Ribosomal Protein L13
Uacc-1598 Cell Line
Skov3 Cell Line
 NM_012423.2
F: CGGACCGTGCGAGGTAT
R: CACCATCCGCTTTTTCTTGTC
 114 58-62 SYBR

Molecular Types:

mRNA

Evaluation Methods

NormFinder

Contact

Name: SONGBIN FU
Email: fusongbin@yahoo.com
Institution: Laboratory of Medical Genetics, Harbin Medical University, Harbin, Heilongjiang 150081

Reference

RPL13A as a reference gene for normalizing mRNA transcription of ovarian cancer cells with paclitaxel and 10-hydroxycamptothecin treatments.
Bian Z, Yu Y, Quan C, Guan R, Jin Y, Wu J, Xu L, Chen F, Bai J, Sun W, Fu S.
Molecular medicine reports. 2014-12-17