DLGAP1-AS2

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LncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2),one kind cytoplasmic long non-coding RNA,was up-regulated in glioma and was quite correlated with poor prognosis of glioma patients.

Annotated Information

Name

Approved symbol:DLGAP1-AS2

Approved name:DLGAP1 antisense RNA 2

HGNC ID:28146

Previous names:DLGAP1 antisense RNA 2 (non-protein coding)

Alias symbols:MGC11082

RefSeq ID:NR_119377

LncBook ID:[1]

Characteristics

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Function

Depletion of DLGAP1-AS2 in glioma cells could inhibit cell proliferation and cell migration, and induce cell apoptosis, resulting in the suppression of the progression of glioma consequently. [1].

Regulation

LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression[1].

Yes Associated Protein 1 (YAP1) was the downstream target of DLGAP1-AS2 and DLGAP1-AS2 modulated glioma cell proliferation, migration and apoptosis via regulating YAP1[1].

Diseases

  • glioma cells [1]

Labs working on this lncRNA

  • Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.[1].

References

  1. 1.0 1.1 1.2 1.3 1.4 Miao W, Li N, Gu B, Yi G, Su Z, Cheng H. LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression. J Biochem. 2020 Apr 1;167(4):411-418. doi: 10.1093/jb/mvz108.