GTSCR1
Contents
Annotated Information
Approved Symbol
GTSCR1
Approved Name
Gilles de la Tourette syndrome chromosome region, candidate 1 (non-protein coding)
Characteristics
GTSCR-1 encodes a putative product of 138 aa in three exons; the protein shows no significant homology to other proteins, ESTs, or protein motifs.[1]
Mutation
DHPLC evaluation of coding regions and intron–exon splice junctions for the transcripts GTSCR-1 reveals no missense or nonsense mutations in a group of 96 patients with GTS, OCD, and CT (Tables 1 and 2, which are published as supporting information on the PNAS web site).[1]
Diseases
Gilles de la Tourette syndrome (GTS)[1]
Sequence
>gi|512125225|ref|NM_001278515.1| Homo sapiens Gilles de la Tourette syndrome chromosome region, candidate 1 (non-protein coding) (GTSCR1), mRNA
000001 CTGCATCTAG GTCTCTGCCT GAGCTCAGGT TCCCTAAAAA GCCTGGTCTG AGGCAATGAC TAAAAAGGCT CCTATTTTGT 000080
000081 TTAAGGACGT GCAAACTCAT GGCAAGAAGG TGAGGAAAAC AGCTACGGAG GGAAGGATGA GAAGCAATGC AAAGTGACAT 000160
000161 ATACCATCCT GGCCACAGCT TCCCAAGTTG GGTCCTTTGC TGGGTGCACT CATGTGGCCA TGAGGGACAT CTCAGAGAGA 000240
000241 CTGCAGAGAT CAGAAAAACT CATCAAAATG GAGACCTGCA AATAAGAGGA GGAAGAGGGA GGAGAGAGAG CACAGAAATC 000320
000321 TTCCAAGTGG CTTCAGTGAC AGAAGGGGAG GAGTCACCAC CTGCCATTTG CATGGAAGTG TTTTTGTTCC TCTGGTTTAT 000400
000401 TGCTCCTATT TATGCATGCG TGTGCAGGAT CTTCAAAATC CAGGTAAGAA ACACAGTGAA GAACTCATCT ACTGCAAGCT 000480
000481 TGGCCCCATC CATCAGTACC AGTGAAGAGA GACAAATCAG GATAGAAAGA CATCACTACC ATCTCTATGG TCAGTGATAT 000560
000561 TATGGACTAA TGAATAAAAA TAACTGCTTT ACACAGGA
000081 TTAAGGACGT GCAAACTCAT GGCAAGAAGG TGAGGAAAAC AGCTACGGAG GGAAGGATGA GAAGCAATGC AAAGTGACAT 000160
000161 ATACCATCCT GGCCACAGCT TCCCAAGTTG GGTCCTTTGC TGGGTGCACT CATGTGGCCA TGAGGGACAT CTCAGAGAGA 000240
000241 CTGCAGAGAT CAGAAAAACT CATCAAAATG GAGACCTGCA AATAAGAGGA GGAAGAGGGA GGAGAGAGAG CACAGAAATC 000320
000321 TTCCAAGTGG CTTCAGTGAC AGAAGGGGAG GAGTCACCAC CTGCCATTTG CATGGAAGTG TTTTTGTTCC TCTGGTTTAT 000400
000401 TGCTCCTATT TATGCATGCG TGTGCAGGAT CTTCAAAATC CAGGTAAGAA ACACAGTGAA GAACTCATCT ACTGCAAGCT 000480
000481 TGGCCCCATC CATCAGTACC AGTGAAGAGA GACAAATCAG GATAGAAAGA CATCACTACC ATCTCTATGG TCAGTGATAT 000560
000561 TATGGACTAA TGAATAAAAA TAACTGCTTT ACACAGGA
Labs working on this lncRNA
- Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA. Matthew.State@Yale.edu
References
- ↑ 1.0 1.1 1.2 State MW, Greally JM, Cuker A, Bowers PN, Henegariu O, Morgan TM, Gunel M, DiLuna M, King RA, Nelson C, Donovan A, Anderson GM, Leckman JF, Hawkins T, Pauls DL, Lifton RP, Ward DC. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4684-9.
