HAND2-AS1
Contents
Annotated Information
Approved Symbol
HAND2-AS1
Approved Name
HAND2 antisense RNA 1 (head to head)
Synonyms
DEIN, NBLA00301, FLJ11539
Chromosome
4q34.1
RefSeq ID
NR_136198
Diseases
- Neuroblastoma
Ensembl ID
ENSG00000237125
pubmed IDs
18171985, 19348682
Characteristics
Schematic representation of HAND2-AS1 sequence conservation in different species. [1].
HAND2-AS1 is located on chromosome 4q33–34 in a head-to-head orientation with HAND2 with both genes being separated by a nucleotide sequence of 228 bp.[2]
The only putative start codon of HAND2-AS1 in a strong context is located in exon 4 and corresponds to the coding sequence of XM_496724.[1]
Expression
Northern blot analysis reveal strong HAND2-AS1 expression in five stage IVS tumors and weak HAND2-AS1 expression in six stage IV tumors.[1]
Function
HAND2-AS1 may contribute to the molecular definition of particular subtype of neuroblastoma.[1]
Evolution
The nucleotide sequences of HAND2-AS1 variants A and B are conserved among various mammals such as dog, mouse, and rat,with similarities ranging from 62% to 71%.[1]
Sequence
>gi|1015576906|ref|NR_136198.1| Homo sapiens HAND2 antisense RNA 1 (head to head) (HAND2-AS1), transcript variant 8, long non-coding RNA
000001 GATTGGCTAC CTCCTCATAA CCATAAGATA ATTAAAACTT GGCGGGGGGG GGGGGCAGGG TTAAAAAAAC TTTTTTTATC 000080
000081 AGTCAGAGGA TAATGCAAGT GTTTAACAGA TGCTTCACTA TTAAAATATT TTCCCCCCAA GTCTCAAATA TTGAAGAATC 000160
000161 TCTAACCAGA AGGCACAGAT CATTCATGGG GATGTATAAC CGAAACCAGT CCTCTCCACC GCCTGGGGAT CTTCACTTTC 000240
000241 GCAGTCTACG ACTGCCTGTG ACTCCAGAAA GACAAACTGC AGATTGGCCA AGCTGCCTGA AGACCCAGCC CGACAGCGAT 000320
000321 GCCTGTCAGC CCGCGTCGCC CACCAGGGCA GCTGCTCTCC CAACTCGCAT GGGGGGCACC ACCCCGCCTC GGTGCCCTAG 000400
000401 AGCTGAGCGC AGCCGCGGCT CCACGGGGAT CGCCAGGGCC TCAGCCCTCG CGGCCGGCGG CGCGGGAGTG TTGCGGGGCA 000480
000481 GGGACCAGAG CGCGATCAGA GCGGCCACCC CCGATTTAGG TCGCCAGCTT TCCAGTCACT GCGATGGCCA CTGGGGCGCC 000560
000561 CCTTCCATCC TGGTTAAATT CTCATTGTGA TCCCCAGCCC TCTTCTCGGT TCCCCACACC CAGGAGGCCG GTTCTCCGCC 000640
000641 GCTCAGGCTG GGAGAGGTCA CCGCTCCGGG CAGGGTGGAC CCCCAGCTCC GTCTCGGAGG ACCTTTCGCC GGAGGCGAGC 000720
000721 AGGAAGGGGT TAACCATGAG CCTCCCACCC TCACCTCCCA GACCCTGGTG CCGGGCTAAG GCCTCCGCTT CCCTCCTGAG 000800
000801 GTCTCATTAG GAAACCCTCA CCGCTATTTT CAACATTTCC TCAATCAAGT GCCTTTAAAT AGAGCTGCAC AAACAGATTG 000880
000881 GCGGCAAAAG CGTAGATCTT GTCACGATTG AGACCAATCC AGTATTTCAG CCTTGTTTGC TTTGCAATTA CGGGTTGGCT 000960
000961 TGTGGCTACG GTGCCACCGG GGCAAATCTG CAGCCGCTCG CTTTCTCCTC TGCGCTCCGG GCGGGTGGAG GAAGCGACCC 001040
001041 GCGGAGTCAC TGCAGGGAGG AGAGGGGGAC GCGCGCGGGG GGAGGCGGCG GAGGGCGGAG GAGACTCGCT TGCACCCCAG 001120
001121 GGCCGCGGGC ACGCAGAGCT GTGTTGAAGG ACATACTTTT CAGGTTCCTG ACAGTCACTG AGCTATACGC AATAATAAAG 001200
001201 TGCGTGATTC GCGTGTGGAA ACCAGTGTCG TGTCCTTACC AGCTTCCTTT TCTGTCCACC TTCCCTCTCT CTTCTACCTC 001280
001281 CGTTTCGCTT TTCTTCAGTG CATGTTAGCG GTTTGCTGGA TTTCCCTTCT CCCTCGCTGT TCAACTGCTA GCATGATTTG 001360
001361 TTACATTTTC CACAGCTGTT TATTCTTGTT TGACTTTTTG TACAAAGTCA CTTTAAATCT GCTGCAGAAA GAATAAAGCA 001440
001441 CCTAGCCCTT TGGATGGACT CCTGCAGGCG TGTGGCTGTC CCTGGCCCAC TTTTAATTCT TTGGAGATGG CTCTTCTGTG 001520
001521 TAAATCAGCT GCTGGGTGCG TTCGGTCACC TCGTAGGCCA GCCTAGTTTG TATCAGCAGA ACAGTAGTGG ACTCGACTCA 001600
001601 GGTCGTAAGC CTTATATTTC ACAGACAATT AAATCTTGGC TGCTGTTGAA CAAAACTGTA ATATTTACTT TGTTCTATAC 001680
001681 CGAGAAGCAC TTTTAAAGTA AAAAAGAAAA AAAAACCAAA TACTACACTT CAAAAAGAAA ATATGACAAT GAATCTCTTT 001760
001761 TTATGGATTC TCTCTGCATA AGTGGAAACA ATATGATTTA AATCCCCAAC ACCCCATCCC CCTTTTCAGA CACAGCTGAA 001840
001841 GTGATACAGA TACTGTCTTC TAACACATAA TCTCCCTCTC TCGGGAGAGG CACCTGCCTG TGCTACATTC GATTTAGTTT 001920
001921 GTAAGGTTTC AGGCCCCTCC CCGACCCATG TAATATGTAA CAAGGATTAT CAAATAATAA GGTCTTGGAT GTGAAGTCTG 002000
002001 CTTTACACAA GAATTCAAGA AAGATAGGCA GGACTTGAGT AATTATGTTA CAACTTCATA TTACTTTCCA AATGAATACC 002080
002081 CATTTTCTTC TCATGTCAAC TTCTAGAGAT GGGATGCTGA GGCAGAGAAA TATTTTTATG AGACTCTGGA GTACATACTA 002160
002161 AAATGTGCTT CCTTATTATT TAAGAATGTG TAAGGTATGG ACCTACATTT GTTTGCTGGT GGTCATAAAA TAAATTCATA 002240
002241 GCCATTGTGG CCAATAAGCA ATCTCCTTCA CGCTTTAAAA GTTTTTGGTT TATAATCCCA CCTGGATTGT ATTTTCACTA 002320
002321 TTCTGTATCA CCCTCCTATT GCAATATTTT GGTTCTCAAT CTTATGTAAA GCAAACCTCA GAAATGATCG TTTCCATAAA 002400
002401 ATTGTGCAAT GGCAAAGCCA CAGAATAATA TTTTGAGTCC ATATAGCCGT GCATGCTCAT CTATATAGCT CTTATACAGT 002480
002481 TTTCTAGCTG ATTGCTTTGG TATTTCAAGA AATAGGAAGC AGTAGCTACC TATTTTAATG AAAGGGTACC ATTTCATAAG 002560
002561 AATTCTATTT TCACTGAAAA AATTGGTCTG GCACATTATT CAATGCAAAA GATTATAATA TTACTTTCAC GTGTGTTAAT 002640
002641 CTGTTTAGTA TAAAACTGCT AGGGTGTCTT AACCATTAAC GCGTTTTGCC ACACTACTTT CAAATGGTGA TCTGAGATAA 002720
002721 TTACGAAGAT TTTGATGTTA ATCCCACGTT AAATGAACAA CTATGAAAAT AATCTTAAAG CATTATTACT CCCATATACA 002800
002801 TGCCAGCAAA CCCAATTGTG GAGAGAACAT GATTACTTTT TATCTGACAT TATCCTATAA GGATATGGCT ACATTTATTT 002880
002881 CTTTTAAAAT TGGAGCAGTT TTCAATTACT TTTTAACAGA ATTGTTTTCA ACACAGCATT TTGCAGTGCC CATAAACCAT 002960
002961 AGCAACTTTG TCCTGATCGA TACATATTTT TCTGCATTAT TATTCATTAG CCTCTTTGCA AACTCACTAA AATAGAATAG 003040
003041 TATTAAAGTA TGAATATATA GAGAACAATT ATTAGGTTCT ACATATTTAT TTAGGTAAAC CAATGTTATT AAAATTAAAA 003120
003121 ACATGTGCCT GGCATATAAG TGCTTCTTCA GGAATTCTTT TTTGGATGCA TAGTTATTAT TTTTTAAACA AACTCAGATT 003200
003201 TTCAAACACT GATTTTCTTC TCTGAACGGG CATTGCATTG TTTTAAACAG TAGCTCCTGG AATAATGCCA CCTTTAGTAT 003280
003281 TTTAGACTTT CAAACAACAA TTGGAATTGG ATAAATGCTT TCAGCTGGGA GCACTTTCCT AATACCTTTG TAGGTAATGG 003360
003361 GATTCTCTAT TTGTGCTGGG TGACAAACGG ACAGTGCCCT GGACAGACTG CCTACCCTCT GCAGAATCTA CCAAAAAGTA 003440
003441 GAGTTTTCCC ATGAGACTGC TTGTGGTCCA TCTAAAAATG AAAAAATAAT CAGAGAAAAT GCGCAAAGCC TTTTCTAACT 003520
003521 ACAGTTATGA AATGATGGCT TAAAGAGGTA TTTAGAAAAT AAGAGTGGAG TAATACAGAA ACAAAATCTG AAGAAGAAAG 003600
003601 TTTGCTTAGG AGCTGATGCT CTTTGTCTAC AAACAAGAGG GTAAGGAGCT GGATCCAATT GAATTGAATT GTTTTTGTTT 003680
003681 GCTTGTTTGT TTTCTTCCAT TCAGTGCCTT TCAAACTGTT TTTTACTGGA TGAAGAAACT CAACCAAGAA AATATATGTC 003760
003761 GATTCTTGTA TATGGGACAA TATTAGCTGC TGTGATTTTT AATACTAGCA TAAAATATAA GAATCTTTTT ATTACTGTGA 003840
003841 TATTGTTTTT TCCTAAATGA ATGCATAGTG TAACAATTGG TGTCAAAAAG CATTGAATTT TTTTCAGATG GATTAAGCTG 003920
003921 GAATAATAAA GTATATCTAT GAGATGATTT CTGTAAACTC TGACTTGCTG AGAAAAAAGT GAAAAAGCTT TTTCTGGAAG 004000
004001 AAACATGGCA ACTTAACCGT TATTAATCTG GACTAAATAA AACAGGAAAC TGCTTCTTTA CATTTCTAGT AATTTTTTCT 004080
004081 GCTTTTCCAA ACATTGTTAA GTTCTATGCA ACTTGTGCTA TTCAAGTAAA GATGATGTCA GTAATAAAAT TACAGAATCT 004160
004161 AAAAAAAAAA AAAAAAA
000081 AGTCAGAGGA TAATGCAAGT GTTTAACAGA TGCTTCACTA TTAAAATATT TTCCCCCCAA GTCTCAAATA TTGAAGAATC 000160
000161 TCTAACCAGA AGGCACAGAT CATTCATGGG GATGTATAAC CGAAACCAGT CCTCTCCACC GCCTGGGGAT CTTCACTTTC 000240
000241 GCAGTCTACG ACTGCCTGTG ACTCCAGAAA GACAAACTGC AGATTGGCCA AGCTGCCTGA AGACCCAGCC CGACAGCGAT 000320
000321 GCCTGTCAGC CCGCGTCGCC CACCAGGGCA GCTGCTCTCC CAACTCGCAT GGGGGGCACC ACCCCGCCTC GGTGCCCTAG 000400
000401 AGCTGAGCGC AGCCGCGGCT CCACGGGGAT CGCCAGGGCC TCAGCCCTCG CGGCCGGCGG CGCGGGAGTG TTGCGGGGCA 000480
000481 GGGACCAGAG CGCGATCAGA GCGGCCACCC CCGATTTAGG TCGCCAGCTT TCCAGTCACT GCGATGGCCA CTGGGGCGCC 000560
000561 CCTTCCATCC TGGTTAAATT CTCATTGTGA TCCCCAGCCC TCTTCTCGGT TCCCCACACC CAGGAGGCCG GTTCTCCGCC 000640
000641 GCTCAGGCTG GGAGAGGTCA CCGCTCCGGG CAGGGTGGAC CCCCAGCTCC GTCTCGGAGG ACCTTTCGCC GGAGGCGAGC 000720
000721 AGGAAGGGGT TAACCATGAG CCTCCCACCC TCACCTCCCA GACCCTGGTG CCGGGCTAAG GCCTCCGCTT CCCTCCTGAG 000800
000801 GTCTCATTAG GAAACCCTCA CCGCTATTTT CAACATTTCC TCAATCAAGT GCCTTTAAAT AGAGCTGCAC AAACAGATTG 000880
000881 GCGGCAAAAG CGTAGATCTT GTCACGATTG AGACCAATCC AGTATTTCAG CCTTGTTTGC TTTGCAATTA CGGGTTGGCT 000960
000961 TGTGGCTACG GTGCCACCGG GGCAAATCTG CAGCCGCTCG CTTTCTCCTC TGCGCTCCGG GCGGGTGGAG GAAGCGACCC 001040
001041 GCGGAGTCAC TGCAGGGAGG AGAGGGGGAC GCGCGCGGGG GGAGGCGGCG GAGGGCGGAG GAGACTCGCT TGCACCCCAG 001120
001121 GGCCGCGGGC ACGCAGAGCT GTGTTGAAGG ACATACTTTT CAGGTTCCTG ACAGTCACTG AGCTATACGC AATAATAAAG 001200
001201 TGCGTGATTC GCGTGTGGAA ACCAGTGTCG TGTCCTTACC AGCTTCCTTT TCTGTCCACC TTCCCTCTCT CTTCTACCTC 001280
001281 CGTTTCGCTT TTCTTCAGTG CATGTTAGCG GTTTGCTGGA TTTCCCTTCT CCCTCGCTGT TCAACTGCTA GCATGATTTG 001360
001361 TTACATTTTC CACAGCTGTT TATTCTTGTT TGACTTTTTG TACAAAGTCA CTTTAAATCT GCTGCAGAAA GAATAAAGCA 001440
001441 CCTAGCCCTT TGGATGGACT CCTGCAGGCG TGTGGCTGTC CCTGGCCCAC TTTTAATTCT TTGGAGATGG CTCTTCTGTG 001520
001521 TAAATCAGCT GCTGGGTGCG TTCGGTCACC TCGTAGGCCA GCCTAGTTTG TATCAGCAGA ACAGTAGTGG ACTCGACTCA 001600
001601 GGTCGTAAGC CTTATATTTC ACAGACAATT AAATCTTGGC TGCTGTTGAA CAAAACTGTA ATATTTACTT TGTTCTATAC 001680
001681 CGAGAAGCAC TTTTAAAGTA AAAAAGAAAA AAAAACCAAA TACTACACTT CAAAAAGAAA ATATGACAAT GAATCTCTTT 001760
001761 TTATGGATTC TCTCTGCATA AGTGGAAACA ATATGATTTA AATCCCCAAC ACCCCATCCC CCTTTTCAGA CACAGCTGAA 001840
001841 GTGATACAGA TACTGTCTTC TAACACATAA TCTCCCTCTC TCGGGAGAGG CACCTGCCTG TGCTACATTC GATTTAGTTT 001920
001921 GTAAGGTTTC AGGCCCCTCC CCGACCCATG TAATATGTAA CAAGGATTAT CAAATAATAA GGTCTTGGAT GTGAAGTCTG 002000
002001 CTTTACACAA GAATTCAAGA AAGATAGGCA GGACTTGAGT AATTATGTTA CAACTTCATA TTACTTTCCA AATGAATACC 002080
002081 CATTTTCTTC TCATGTCAAC TTCTAGAGAT GGGATGCTGA GGCAGAGAAA TATTTTTATG AGACTCTGGA GTACATACTA 002160
002161 AAATGTGCTT CCTTATTATT TAAGAATGTG TAAGGTATGG ACCTACATTT GTTTGCTGGT GGTCATAAAA TAAATTCATA 002240
002241 GCCATTGTGG CCAATAAGCA ATCTCCTTCA CGCTTTAAAA GTTTTTGGTT TATAATCCCA CCTGGATTGT ATTTTCACTA 002320
002321 TTCTGTATCA CCCTCCTATT GCAATATTTT GGTTCTCAAT CTTATGTAAA GCAAACCTCA GAAATGATCG TTTCCATAAA 002400
002401 ATTGTGCAAT GGCAAAGCCA CAGAATAATA TTTTGAGTCC ATATAGCCGT GCATGCTCAT CTATATAGCT CTTATACAGT 002480
002481 TTTCTAGCTG ATTGCTTTGG TATTTCAAGA AATAGGAAGC AGTAGCTACC TATTTTAATG AAAGGGTACC ATTTCATAAG 002560
002561 AATTCTATTT TCACTGAAAA AATTGGTCTG GCACATTATT CAATGCAAAA GATTATAATA TTACTTTCAC GTGTGTTAAT 002640
002641 CTGTTTAGTA TAAAACTGCT AGGGTGTCTT AACCATTAAC GCGTTTTGCC ACACTACTTT CAAATGGTGA TCTGAGATAA 002720
002721 TTACGAAGAT TTTGATGTTA ATCCCACGTT AAATGAACAA CTATGAAAAT AATCTTAAAG CATTATTACT CCCATATACA 002800
002801 TGCCAGCAAA CCCAATTGTG GAGAGAACAT GATTACTTTT TATCTGACAT TATCCTATAA GGATATGGCT ACATTTATTT 002880
002881 CTTTTAAAAT TGGAGCAGTT TTCAATTACT TTTTAACAGA ATTGTTTTCA ACACAGCATT TTGCAGTGCC CATAAACCAT 002960
002961 AGCAACTTTG TCCTGATCGA TACATATTTT TCTGCATTAT TATTCATTAG CCTCTTTGCA AACTCACTAA AATAGAATAG 003040
003041 TATTAAAGTA TGAATATATA GAGAACAATT ATTAGGTTCT ACATATTTAT TTAGGTAAAC CAATGTTATT AAAATTAAAA 003120
003121 ACATGTGCCT GGCATATAAG TGCTTCTTCA GGAATTCTTT TTTGGATGCA TAGTTATTAT TTTTTAAACA AACTCAGATT 003200
003201 TTCAAACACT GATTTTCTTC TCTGAACGGG CATTGCATTG TTTTAAACAG TAGCTCCTGG AATAATGCCA CCTTTAGTAT 003280
003281 TTTAGACTTT CAAACAACAA TTGGAATTGG ATAAATGCTT TCAGCTGGGA GCACTTTCCT AATACCTTTG TAGGTAATGG 003360
003361 GATTCTCTAT TTGTGCTGGG TGACAAACGG ACAGTGCCCT GGACAGACTG CCTACCCTCT GCAGAATCTA CCAAAAAGTA 003440
003441 GAGTTTTCCC ATGAGACTGC TTGTGGTCCA TCTAAAAATG AAAAAATAAT CAGAGAAAAT GCGCAAAGCC TTTTCTAACT 003520
003521 ACAGTTATGA AATGATGGCT TAAAGAGGTA TTTAGAAAAT AAGAGTGGAG TAATACAGAA ACAAAATCTG AAGAAGAAAG 003600
003601 TTTGCTTAGG AGCTGATGCT CTTTGTCTAC AAACAAGAGG GTAAGGAGCT GGATCCAATT GAATTGAATT GTTTTTGTTT 003680
003681 GCTTGTTTGT TTTCTTCCAT TCAGTGCCTT TCAAACTGTT TTTTACTGGA TGAAGAAACT CAACCAAGAA AATATATGTC 003760
003761 GATTCTTGTA TATGGGACAA TATTAGCTGC TGTGATTTTT AATACTAGCA TAAAATATAA GAATCTTTTT ATTACTGTGA 003840
003841 TATTGTTTTT TCCTAAATGA ATGCATAGTG TAACAATTGG TGTCAAAAAG CATTGAATTT TTTTCAGATG GATTAAGCTG 003920
003921 GAATAATAAA GTATATCTAT GAGATGATTT CTGTAAACTC TGACTTGCTG AGAAAAAAGT GAAAAAGCTT TTTCTGGAAG 004000
004001 AAACATGGCA ACTTAACCGT TATTAATCTG GACTAAATAA AACAGGAAAC TGCTTCTTTA CATTTCTAGT AATTTTTTCT 004080
004081 GCTTTTCCAA ACATTGTTAA GTTCTATGCA ACTTGTGCTA TTCAAGTAAA GATGATGTCA GTAATAAAAT TACAGAATCT 004160
004161 AAAAAAAAAA AAAAAAA
Labs working on this lncRNA
- Department of Pediatric Oncology and Hematology and Center of Molecular Medicine Cologne,University Children’s Hospital, Cologne, Germany.[1][2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Voth, H., A. Oberthuer, T. Simon, Y. Kahlert, F. Berthold, and M. Fischer. "Identification of Dein, a Novel Gene with High Expression Levels in Stage Ivs Neuroblastoma." Mol Cancer Res 5, no. 12 (2007): 1276-84.
- ↑ 2.0 2.1 Voth, H., A. Oberthuer, T. Simon, Y. Kahlert, F. Berthold, and M. Fischer. "Co-Regulated Expression of Hand2 and Dein by a Bidirectional Promoter with Asymmetrical Activity in Neuroblastoma." BMC Mol Biol 10, (2009): 28.
