LASTR
The stress-induced long non-coding RNA (lncRNA), LASTR (lncRNA associated with SART3 regulation of splicing), is upregulated in hypoxic breast cancer and is essential for the growth of LASTR-positive triple-negative breast tumors.[1]
Contents
Annotated Information
Name
Approved symbol:LASTR
Approved name:lncRNA associated with SART3 regulation of splicing
HGNC ID ;HGNC:54143
Previous name:long intergenic non-protein coding RNA 2657
RefSeq ID:NR_134491
Characteristics
Please input information here.
Function
LASTR promotes splicing efficiency by controlling SART3 association with the U4 and U6 small nuclear ribonucleoproteins (snRNP) during spliceosome recycling[1].
Regulation
Intron retention induced by LASTR depletion downregulates expression of essential genes, ultimately decreasing the fitness of cancer cells.[1]
Expression
LASTR is upregulated in several types of epithelial cancers due to the activation of the stress-induced JNK/c-JUN pathway.[1].
Diseases
- hypoxic breast cancer.[1]
Labs working on this lncRNA
- VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.[1]
- Department of Oncology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.[1]
- VIB Proteomics Core, Albert Baertsoenkaai 3, 9000 Ghent, Belgium.[1]
- Department of Biomolecular Medicine, Ghent University, B-9000 Ghent, Belgium.[1]
- VIB Center for Medical Biotechnology, B-9000 Ghent, Belgium.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 De Troyer L, Zhao P, Pastor T, Baietti MF, Barra J, Vendramin R, Dok R, Lechat B, Najm P, Van Haver D, Impens F, Leucci E, Sablina AA. Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3. Nucleic Acids Res. 2020 Mar 18;48(5):2502-2517. doi: 10.1093/nar/gkz1237. Erratum in: Nucleic Acids Res. 2020 May 21;48(9):5198-5199. PMID: 31956895; PMCID: PMC7049684.
