LINC00174

Overexpression of LINC00174 in colorectal cancer (CRC) tissues and cells correlates with poor prognosis and might be critical to CRC progression.

Annotated Information

Name

Approved symbol:LINC00174

Approved name:long intergenic non-protein coding RNA 174

HGNC ID:27788

Previous name:non-protein coding RNA 174

RefSeq ID:NR_026873

Characteristics

Long intergenic non-protein coding RNA 174 (LINC00174) (NR_026873.1), is located on chromosome 7q11.21 and has a transcript length of 4426 nucleotides ^[1].

Function

LINC00174 contributes to CRC progression by regulating miR-1910-3p/TAZ signal pathway. Oncogenic role of LINC00174 in clinical specimens and cellular experiments has been identified, showing the potential LINC00174/miR-1910-3p/TAZ pathway ^[1].

Diseases

Colorectal cancer (CRC) ^[1]

Expression

Increased expression of LINC00174 has been observed in CRC tissues and cells in comparison to their corresponding controls ^[1]. Also, the aberrant overexpression of LINC00174 indicated the poor prognosis of CRC patients ^[1].

Experiment	Forward primer	Reverse primer
qRT-PCR	5'-GGCCCAACACTTCCCTCAAA- 3'	5'-CAGGGAGAAACGACCTGGAG- 3'^[1]

Labs working on this lncRNA

Department of Geratology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. ^[1]
Department of Endocrinology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. ^[1]
Department of Gastroenterology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. ^[1]
Department of Endocrinology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. ^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Shen Y, Gao X, Tan W, Xu T. STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. Gene. 2018, 666:64-71.

Sequence

>gi|285908|ref|NR_026873.1| Homo sapiens long intergenic non-protein coding RNA 174 (LINC00174), long non-coding RNA

000001  GTGGTTTGAT CTTGGCTCAC TGCAGTCTCA ACCTCTCAGG CTCAAGCTAT CCTTCTGCCT CAGACTCTGG GGTAGCTGGG  000080
000081  ACAACAGCCT CAGCCAAGAT GTCTCACCCT ACTCTCTATG ATGCAACAAG AAGCCCCTGG GGAATGTTTC AGTCCCAGTC  000160
000161  TGTACTATTG TCATGTGCTC ATCACAGTCT GGTGGAATTT AAATGACCTT TTATCAAGAT GGATAAACGC AAGTTTCCCA  000240
000241  GTGCTGGAAT ACAGAAAATG GATGGACAAA CAGGGTCTTG CTCTGTTGTC CAGGCTGGAG TGCGGTAGTG CTATCACAGC  000320
000321  TGACTGCATC CTCAACCTCT CAGGCTCAAG CAGTCCTCCC ACCTCAGCCT CCCAGGTGGC TGAGACTGTA CGTGCTTGCC  000400
000401  ACAATGCCCA ACTAATAATT TGGACTTTTC CTATACATGG GTTCCAAAGG GCTGACTGCG AAACGAAGTG ACCTCACAAT  000480
000481  GACTCAAGCT ACCACTTAGT GTTGATTGTG ATGAAATGCC AGCTGTGGCA TATGCCTTGG GAGCTAAGTG GCTGCTGCAC  000560
000561  TTGACCACTA TGAAGACTGG TGTGGAAGGG TCCTTCTGGA TGTACTTGGG CAGGGTCCCC AACGCCAGAG CCATGGAACT  000640
000641  GTAAGGAGCC ACACAGCCGG AGGTGAATGG TGTTGAATGA GGGAAGCTTC ATCTGTGTTT ACAGCCACTC CCCATTGCTC  000720
000721  ACATTCCTGC CTGAGCTCTG CCTTCTCTCA GATCAGCAGC AGCATTAGAT TCTCATAGGA GCATGCACCC CATTGTGAAC  000800
000801  CATGCATGTG AGGGATCTAC GTTGCGCTGT CCCTATGAGA ATCTAATGCC TGATGCTCTG TCACTTTCTC CAATATTATC  000880
000881  TTCAAGTGAG CCACTCCTGG CCCAATTCCT GTCTCCCGTT GGCCTATAGA GGCCAAGCCT CTGCCTCATG ATGGCCTCTG  000960
000961  CAGGTCAAGC TCCTCCTCCT GGTTCCGTCT ACAGGCCCAA CACTTCCCTC AAATAAACTC TTCTGCCCAG CTCCTGTCCA  001040
001041  GCTCACGGCA GCCACTGTCG GCATGAAAAT TCCTCAATTC AAGCTCTCTA GGCCCACCTT CTGCCTCCCA CTGGCCTGGA  001120
001121  CACGCCCAGC TCCAACCTGA CAATGGTCTC TACAGGCCCA GCTCATCGGG CTCTGAGGGA CCTCTCCAGG CCAAGCTCTT  001200
001201  ACCTCACGGA GGCTTCTCCA GGTCGTTTCT CCCTGTCTTC AGGCAGTGGT GACAGGTCAG CTCCTCCTCC ACAGTGGCCT  001280
001281  CGTTTGGGCA GGTCCTGCCT CTTGCAGCCT CTCAAAGCCC AGCTCCTGCC TCTGAGTGGC TTCTGCGCAC CCAAATGTCC  001360
001361  TCCAGTCAGC CTGTCCTGGC TGAGCTCCTG CGACCTGGCT GAGCTCCTGC CTCCTGTCGG CCTCTATAAA CCCAGCCTCT  001440
001441  GCTGTATGGT GGCTTCTTCA GGCCCAGCTC TTCCTCCTGG CGGTGTATAC AGGTCCAACT CCTGCTTCCC AATGGACTCT  001520
001521  TTAGGCCAGG CTCATGCCTT ACGGCAGCCT TTCCTGGCCC AGCTTTTGCC TGTTGGCATA CCCTCCAGGC CCACAATGTA  001600
001601  CTCAGATCAG CCACTCCATT CCCAGCTCTT CTTCCTGGCT GTGTCTACAG GCCCAACTGC TGCCTCACAA CACCCTCTTT  001680
001681  TGGCCCAGCT CCTGCCCAGC ACCTGGTGGC CTCTATATGC CCCAGACTTC TTAAAGTCAA CTTTGCTAGG CCCACCTTTG  001760
001761  GCCTCCCAGC GGCTTTGACA GGACCAGCTC TTGCCTCATG GCAGCTTCCC AACGCCAGGT TTCTGCCTGC ATTGTGGCAT  001840
001841  CCTTGATGGA CCCAACTCTT GCTTTATGCC GGCCTTCCCA CACCAAGTTT CTGCCTGCCT CATGGCAGGA TCCGATAGGC  001920
001921  CCAGCTCCTG CCTCTAATGG CCTGGTTAGG CTCATCTCAT CCCTCAAGGT GGCCACCCCA GATGAAGCTC CTGCCTTTTG  002000
002001  GCAGCCTTTA GAGGCCCAGC TCATGCATCT CATTGCCTCT TGAAGCCCAG CTCATTCCTC AAAACGGCCT ATCCACGCCC  002080
002081  AGCTTTTCCC TTTGGTGGCT TCTCCAGGCC CAGAAATTCC TCAGTTCGGC TTCGCAAGGT GAAGTTGCTG CCTCCCTGTG  002160
002161  CCTTCTCCAG GCCCAGTTCT TCCTCCCAGC TGGGTCTACA GTCCCATCTC CTGACTCAAA ACAACCTATT TTGGCTCGGC  002240
002241  TCCTGCCCAG CACCTGGCGG CCTTTGTAGG CCTAAAGCTT CCTCAAGTCA AGCGTTCCAG GCCCAGATCA TGCTGCCCAG  002320
002321  GGGCCTTCAC AGGCCCAGCT ACTGCCTGAC GATGGCTTCC CCAGGCCCAG GTCTTGCCTT CCCCCAGCCT CCCGAGGCCC  002400
002401  AGCCCTTGCC TCACAGTTGC TTTCCCAGTC CACGTTACAG CCTGTTACCC GACGGCCTTG ACAGACCAAA CTCTTCCTTC  002480
002481  ACACTGGACA GTTTAGGACA AGCTCATACG TCTTCCAGCC TCTCCAGGTC AAGCTCCTGC CTCACACTGG CCTCTATAGG  002560
002561  CCCAGGTGCT GAATCGCAAT GGTCTGTTTA GGTCCATCTC ATGCCTTTCT CAGACTCTCC AAGCGACGAT CTGGCCTGAC  002640
002641  ACTTGCTTCT GTGGGCCATG TGATCACTCA CACTGGCCTC TTTAGGATCA GGGGATGCCT CTCCACAGGC CGAGATCCTG  002720
002721  CCTGTTGTAG GCCCCTTCAG GATGCGCCGC TGCCTGACAG TGGACCCTCC AGGCCTAGAT GTTACGTGAT CATGGCCTCT  002800
002801  GCAGGTCAAG AATTTAAATT TTCGCAGCCT CTATAGGCCA GGCTACTGCC TCCTGATAAT GGCTTCTGCA GGCCCAAATC  002880
002881  GTCCTGAAAT AAGCCTCGCC AGGAACAGCA CGTGTGTTGG ATGCCCGAAC AACCATAGCT TCTCCCGCAC AGTGGCCCAT  002960
002961  GGGGGCCGGG CTCTTGCCTC AGCCTGGCCA CCTCAGGCCC AGTTCTTGCC TGTTGGCGGC CGCTCCAGGC CCGGCTCCTG  003040
003041  CCCCTCGGCC TCCTCTCCAG GCCCAGAACT GGTTCCCGTC GGCCTCTCCA GGCCCAGCTC TCCCGGCCAC CTCCACGGGC  003120
003121  CCAGCTCCTG CCTCACGACA ACCACGTTCG GCCCAGCTCC TGCCCAGCTC CTGGCAGCCG TTGTAGGCCC CAGGCTTCCC  003200
003201  TGCGTTCAGG CCTCCCGGAC CCACCTTCGG CTTTCCGGCG GCCCTGAGAG ACCCGGCTCC TGCCTGCCAG CGGCCTCTCC  003280
003281  CGGCCCAGCT GCGGCCTCAC GTCGGCCTCC CCAGGCCACG TTTCCGCCTG CCTCACGGCA GCCCCGGCAG GCCCGGCTCC  003360
003361  CGCCTGCCGG GGGCCTCTTG AGGAG

[ref1-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Shen Y, Gao X, Tan W, Xu T. STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. Gene. 2018, 666:64-71.

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