LINC00894

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LINC00894, long intergenic non-protein coding RNA 894 contributes to inhibit tamoxifen resistance (TamR) in breast cancer.

Annotated Information

Name

LINC00894: long intergenic non-protein coding RNA 894 (HGNC:48579)

Characteristics

LINC00894 is a long non protein coding RNA gene located at chromosome Xq28. LINC00894-002 exhibits the most sophisticated network pattern and is the most downregulated lncRNA in MCF-7/TamR cells. [1]

Function

LINC00894 inhibits TamR through the miR-200-TGF-β2-ZEB1 signaling pathway. [1]

Regulation

LINC00894-002 is directly upregulated by ERα.[1]

Expression

LINC00894 expression level is lower in tamoxifen resistance MCF-7/TamR cells compared to the sensitive cells. Knocking down LINC00894-002 downregulates expression of miR-200a-3p and miR-200b-3p, upregulates the expression of TGF-β2 and ZEB1, and finally contributes to TamR.[1] LINC00894 has alteration frequency higher than 10% in lung adenocarcinoma (LUAD).[2]

Disease

  • Breast Cancer [1]
  • Lung adenocarcinoma [2]

Labs working on this lncRNA

  • Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.
  • College of Liren, Yanshan University, 066004 Qinhuangdao, China.
  • Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China.
  • Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230026, China. wangxt11@ustc.edu.cn
  • CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Hefei, 230026, China

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Zhang X, Wang M, Sun H, Zhu T & Wang X. Downregulation of LINC00894-002 Contributes to Tamoxifen Resistance by Enhancing the TGF-β Signaling Pathway[J]. Biochemistry (Moscow). 2018, 83(5):603-611.
  2. ↑ 2.0 2.1 Liu B, Chen Y & Yang J. LncRNAs are altered in lung squamous cell carcinoma and lung adenocarcinoma[J]. Oncotarget. 2016, 8(15):24275-24291.

Sequence

>gi|100272228|ref|NR_027456.1| Homo sapiens long intergenic non-protein coding RNA 894 (LINC00894), long non-coding RNA

000001 ACGCCTATAC ACCGCCAAAT CGCTAGGAAG CCACGTATTC ACGAAGCCAC GCAGTGACGT CGCCACGCAC GTACGCACGC 000080
000081 ACTTGCCACA AGGAGACGCT GTTCAGTTTA CCGGATCCTG TCCCGCGCCA GCCAACCAGG ACAAGGCCGG GGAGCTCGAG 000160
000161 ACAGGCAGCC TAGACCAAGA ACCGGAAGGA GGAAAAGGAA CCGGAGGGAG GAAGAGGAGG GGCGGGACGA GACCACCAGG 000240
000241 CAAGAGTCCA AACTTTCCCG CGGCGACCTA ACTGCACCTC CAGTGTCTTC CCCCAGAGGG CACAGAAGCA GCAAGAAGGG 000320
000321 CGGGAACACT TGACTGGGGT CCATGCAGCT CTAGGCTGAG TCTTGCAGGG CTGAGCCCCC CAGGCCTGCT CTCCTGTGTC 000400
000401 CTGGCCGCTC CGTCAGTGCC TGCCAGTGGG GTCCAGAGGG ACCGTTTTTT TAACGCCTCT TTTGCAGTGA GATGCGCCTA 000480
000481 CTTCTCCCTG GAGAAGCTTG AGGAAGCAGA AATGCTGGAG ATGAGCTGCT CCTCACTCTC ACTCCTGGGT GTGCTGGGCA 000560
000561 GTGGGGTGCA ATGTGCACGT AGGTGCACAC TCTCCCTGGG CGGCAGCGAG CAGCAGAGGT CTGATCTGTG GTCGGATGAC 000640
000641 GAGAGGAAGT GCAAGTAAAG CAGCTGCAGC GAGACCTCGT CCGCACAGGG GCTTGTTCTT CTGTGTCTTT GCAGGGCTGT 000720
000721 TTTGGACTCA GTATTCACCT AAGCACTCCA AATTACCCAG CACACCCTGC CTGCATGGCG CTGCGCTGCA CCTTCACTCT 000800
000801 GGTCACGGGT CTGGCAGTCA GCTCACCAAT TCCTCCTGCT TCCCTGGGAC TTGCCGGCTT TTAGCACTGC AATTCACTCA 000880
000881 GCAAACTGGG ACTGTTGGTC ACCCTACCTG GCAGCCAGTG ATAAGGTGAG GGCCACTCCT GGGAGGGAGG ACACCTGTGG 000960
000961 GGAAAATTCT TGTGTTATTT ATTTCTCCTT CGGGATAGGG TGCCTGCAGC GCTTCATGGG AGGGGGTGGG CTGATGCTGC 001040
001041 GGGCTCAGAA GTTTCAAGGG CATCTGGGGA GACCAGATAT TCAGAGACCT TCTAGATGTG CCTGTTCCAT GTATCAGGGA 001120
001121 CGCAGGTTTT CCCAACAGGG CTGGTGTCAT TGGCATGACA GACCTGCCTT GGCTGAGCGT TCACCTGTCT TTGGAGTTCA 001200
001201 GCCACCTTAG CAAGTCCTGG GTTTGTTCTT CAGACTTTGC TGCTCGCCCA TTGCCTGGAT CGGGGGCTAC TTTGTAAACC 001280
001281 ACCAGGAAGA CTCCAGTGTT TCTGGTTAAT TTTTAGATGT TTGTTAATTG CTCTTGGTCT CTCATTAATC CCCTGTGGGT 001360
001361 CATCCAGGAA ACATACTCAC CACTGTCTGT TCTCTGAGTT TTCATTTCCA GGCATCCGCC CTGCCTGGAT CTCCTCACCT 001440
001441 GCCAGGAACT TCCTCTCCAC AAGCCGGCCA TCCCAGCAAA AGTTCTAACA CCAAAGGTCT GGCAACTAGC CTGCCATCTT 001520
001521 GTGCCTGGAG CCGCCTGCGT GCCACCTACT CCCGAAGATG GGAACCTTGT TGCCAGTTGG GCAGATGCGG GGCAATCCTG 001600
001601 TACCAAGACC CCATTTTACC ACCTGCTTTC TCAGACCACT CTGGAACCCA CTGTCTCAGA TTGTGTCCTC CAGGAAGCAG 001680
001681 ACCATGAGAG GGAGTTGGCA GGGCCAAAGA TTTACTGGGG CTAACTAACA CTCAGGAAAG GGATAGGAAG GAAACAGGGC 001760
001761 TGGAGAGCAG GTTGAGCCCG ACCTGACAGT CTCGAGCAGC CCAACAGGGA GGTGTGGAGC AAGGGTTGCC CACTAGAGGG 001840
001841 GCCTGCATTG GGTACGGGTG ATGGGGTCCA CATGGTACCT GGCATATAGC AGGCTGTGCA ATCCATATTA ACTGACTGGA 001920
001921 TAAATTAATG CCCAGAAAAG GTGCCCTGGA GAATGGGTGT GTGCTGAACA CAATAGGGAA GGGCCCAGCA TCTGCCTTGG 002000
002001 CATAGGCAGA ACTGTGCTGT GCCCTGCAAC AGGCCACCTG AGAGCTGCTT TGATCTTGTG TGTACATTAG ATGACTGCCA 002080
002081 GGGGCATGAA GGGGATGTGC TTCCAGGGCA TTTGCTGGCA GGGCGTCTCG TGATCTCTTG GTATTGGTGT GAGCACAGCC 002160
002161 TGGCAGGAGA GGGCAGATCT CCATGCAAAG TATGTCAGAA AGCAGATGGA AGCC